Novel conserved assembly factor of the bacterial flagellum.

نویسندگان

  • Björn Titz
  • Seesandra V Rajagopala
  • Claudia Ester
  • Roman Häuser
  • Peter Uetz
چکیده

TP0658 (FliW) and its orthologs, conserved proteins of unknown function in Treponema pallidum and other species, interact with a C-terminal region of flagellin (FlaB1-3 in T. pallidum; FliC in most other species). Mutants of orthologs in Bacillus subtilis and Campylobacter jejuni (yviF, CJ1075) showed strongly reduced motility. TP0658 stabilizes flagellin in a way similar to FliS, suggesting that TP0658 is a conserved assembly factor for the bacterial flagellum.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Assembly and function of the archaeal flagellum.

Motility is a common behaviour in prokaryotes. Both bacteria and archaea use flagella for swimming motility, but it has been well documented that structures of the flagellum from these two domains of life are completely different, although they contribute to a similar function. Interestingly, information available to date has revealed that structurally archaeal flagella are more similar to bact...

متن کامل

The archaeal flagellum: a different kind of prokaryotic motility structure.

The archaeal flagellum is a unique motility apparatus distinct in composition and likely in assembly from the bacterial flagellum. Gene families comprised of multiple flagellin genes co-transcribed with a number of conserved, archaeal-specific accessory genes have been identified in several archaea. However, no homologues of any bacterial genes involved in flagella structure have yet been ident...

متن کامل

Novel roles for the flagellum in cell morphogenesis and cytokinesis of trypanosomes.

Flagella and cilia are elaborate cytoskeletal structures conserved from protists to mammals, where they fulfil functions related to motility or sensitivity. Here we demonstrate novel roles for the flagellum in the control of cell size, shape, polarity and division of the protozoan Trypanosoma brucei. To investigate the function of the flagellum, its formation was perturbed by inducible RNA inte...

متن کامل

Organelles as virulence factors of an opportunistic pathogen Pseudomonas aeruginosa

Type IV pili (T4P) and flagellum are well known virulence factors of an opportunistic pathogen Pseudomonas aeruginosa. T4P pili provide twitching motility, adherence to biotic/abiotic surfaces, intercellular association that is essential to biophilm formation, and are implicated in chemotaxis, bacteriophage adsorption and DNA uptake. Flagellum provides swimming/swarming motilities and chemotaxi...

متن کامل

کاربری پروتیین‌های جدید در ساخت واکسن استافیلوکوکوس اورئوس

Background: Staphylococcus aureus and Staphylococcus epidermidis are major human pathogens of increasing importance due to the spread of antibiotic resistance. Novel potential targets for therapeutic antibodies are products of staphylococcal genes expressed during human infection. Previously, the secreted and surface-exposed proteins among seroreactive antigens have been discovered. Furthermore...

متن کامل

ذخیره در منابع من

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Journal of bacteriology

دوره 188 21  شماره 

صفحات  -

تاریخ انتشار 2006